Assay Detail
Binding
CHEMBL765465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor
27
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of oxamic acid and acetic acid derivatives related to L-thyronine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.08 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | 4.0 | 2 | 7.00 |
| CHEMBL163067 | — | — | 1 | 6.70 |
| CHEMBL159976 | — | — | 1 | 6.16 |
| CHEMBL163221 | — | — | 1 | 6.10 |
| CHEMBL163268 | — | — | 1 | 6.00 |
| CHEMBL163228 | — | — | 1 | 6.00 |
| CHEMBL559 | DEXTROTHYROXINE | 4.0 | 1 | 5.60 |
| CHEMBL423977 | — | — | 1 | 5.52 |
| CHEMBL163320 | — | — | 1 | 5.40 |
| CHEMBL352126 | — | — | 1 | - |
| CHEMBL163324 | — | — | 1 | - |
| CHEMBL163380 | — | — | 1 | - |
| CHEMBL347713 | — | — | 1 | - |
| CHEMBL159595 | — | — | 1 | - |
| CHEMBL162692 | — | — | 1 | - |
| CHEMBL350199 | — | — | 1 | - |
| CHEMBL441101 | — | — | 1 | - |
| CHEMBL161828 | — | — | 1 | - |
| CHEMBL348983 | — | — | 1 | - |
| CHEMBL350265 | — | — | 1 | - |
| CHEMBL41632 | TIRATRICOL | 3.0 | 1 | - |
| CHEMBL289343 | — | — | 1 | - |
| CHEMBL46882 | — | — | 1 | - |
| CHEMBL350336 | — | — | 1 | - |
| CHEMBL159682 | AXITIROME | 2.0 | 1 | - |
| CHEMBL159334 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1544 | LIOTHYRONINE | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL163067 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1544 | LIOTHYRONINE | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL159976 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL163221 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL163268 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL163228 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL559 | DEXTROTHYROXINE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL423977 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL163320 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL352126 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL163324 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL163380 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL347713 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL159595 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL162692 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL350199 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL441101 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL161828 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL159334 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL348983 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL350265 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL41632 | TIRATRICOL | IC50 | > | 5000.0 | nM | - |
| CHEMBL289343 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL46882 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL350336 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL159682 | AXITIROME | IC50 | > | 5000.0 | nM | - |