Assay Detail
Functional
CHEMBL765509
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of the release of tumor necrosis factor alpha from peripheral blood mononuclear cells
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Imidazole inhibitors of cytokine release: probing substituents in the 2 position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.18 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 6.23 |
| CHEMBL113419 | — | — | 1 | 6.05 |
| CHEMBL142891 | — | — | 1 | 5.96 |
| CHEMBL111456 | — | — | 1 | 5.96 |
| CHEMBL143161 | — | — | 1 | 5.64 |
| CHEMBL143482 | — | — | 1 | 5.60 |
| CHEMBL358042 | — | — | 1 | 5.51 |
| CHEMBL142751 | — | — | 1 | 5.46 |
| CHEMBL359380 | — | — | 1 | 5.44 |
| CHEMBL143480 | — | — | 1 | 5.37 |
| CHEMBL344490 | — | — | 1 | 5.31 |
| CHEMBL142841 | — | — | 1 | 5.30 |
| CHEMBL343230 | — | — | 1 | 5.29 |
| CHEMBL143006 | — | — | 1 | 5.27 |
| CHEMBL87858 | — | — | 1 | 5.27 |
| CHEMBL142571 | — | — | 1 | 5.24 |
| CHEMBL141489 | — | — | 1 | 5.21 |
| CHEMBL356309 | — | — | 1 | 5.19 |
| CHEMBL143007 | — | — | 1 | 5.17 |
| CHEMBL356485 | — | — | 1 | 5.14 |
| CHEMBL358571 | — | — | 1 | 5.14 |
| CHEMBL356983 | — | — | 1 | 5.11 |
| CHEMBL143193 | — | — | 1 | 5.10 |
| CHEMBL143787 | — | — | 1 | 5.06 |
| CHEMBL357648 | — | — | 1 | 4.92 |
| CHEMBL141552 | — | — | 1 | 4.89 |
| CHEMBL142987 | — | — | 1 | 4.88 |
| CHEMBL142694 | — | — | 1 | 4.85 |
| CHEMBL358814 | — | — | 1 | 4.82 |
| CHEMBL344322 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL113419 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL111456 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL142891 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL143161 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL143482 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL358042 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL142751 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL359380 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL143480 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL344490 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL142841 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL343230 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL143006 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL87858 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL142571 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL141489 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL356309 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL143007 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL356485 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL358571 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL356983 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL143193 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL143787 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL357648 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL141552 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL142987 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL142694 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL358814 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL344322 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL356544 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL342338 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL143735 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL143370 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL433933 | — | IC50 | = | 24800.0 | nM | 4.61 |
| CHEMBL142317 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL143786 | — | IC50 | = | 33800.0 | nM | 4.47 |
| CHEMBL142342 | — | IC50 | > | 100000.0 | nM | - |