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Assay Detail

CHEMBL765607

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory concentration against PTP1B using lck as substrate
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Potent reversible inhibitors of the protein tyrosine phosphatase CD45.
Urbanek RA, Suchard SJ, Steelman GB, Knappenberger KS, Sygowski LA, Veale CA, Chapdelaine MJ.
J Med Chem (2001) 44 : 1777 -1793
PubMed 11356112 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.75 4.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL51039 1 4.80
CHEMBL300664 1 4.75
CHEMBL53966 1 4.75
CHEMBL50878 1 4.75
CHEMBL299374 1 4.72
CHEMBL50846 1 -
CHEMBL50627 1 -
CHEMBL51931 9,10-PHENANTHRENEQUINONE 1 -
CHEMBL51317 1 -
CHEMBL51314 1 -
CHEMBL49992 1 -
CHEMBL38066 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL51039 IC50 = 16000.0 nM 4.80
CHEMBL300664 IC50 = 18000.0 nM 4.75
CHEMBL53966 IC50 = 18000.0 nM 4.75
CHEMBL50878 IC50 = 18000.0 nM 4.75
CHEMBL299374 IC50 = 19000.0 nM 4.72
CHEMBL50846 IC50 > 30000.0 nM -
CHEMBL50627 IC50 > 30000.0 nM -
CHEMBL51931 9,10-PHENANTHRENEQUINONE IC50 > 30000.0 nM -
CHEMBL51317 IC50 > 30000.0 nM -
CHEMBL51314 IC50 > 30000.0 nM -
CHEMBL49992 IC50 > 30000.0 nM -
CHEMBL38066 IC50 > 30000.0 nM -