Assay Detail
Binding
CHEMBL765657
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antirhinoviral activity against HRV Protease 3CP (serotype 10)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL289920 | — | — | 1 | 8.40 |
| CHEMBL291277 | — | — | 1 | 8.30 |
| CHEMBL43972 | — | — | 1 | 7.50 |
| CHEMBL44129 | — | — | 1 | 6.96 |
| CHEMBL43385 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL289920 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL291277 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL43972 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL44129 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL43385 | — | EC50 | = | 1410.0 | nM | 5.85 |