Assay Detail
Binding
CHEMBL765659
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Binding affinity against Baculovirus-Expressed hPR-A
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.78 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 8.96 |
| CHEMBL117308 | — | — | 1 | 8.30 |
| CHEMBL117465 | — | — | 1 | 8.00 |
| CHEMBL117586 | — | — | 1 | 8.00 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 7.75 |
| CHEMBL115904 | — | — | 1 | 7.72 |
| CHEMBL93027 | — | — | 1 | 7.70 |
| CHEMBL93463 | — | — | 1 | 6.88 |
| CHEMBL117585 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL117308 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL117465 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL117586 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL1908373 | ONAPRISTONE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL115904 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL93027 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL93463 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL117585 | — | Ki | = | 182.0 | nM | 6.74 |