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Assay Detail

CHEMBL765682

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Binding
Inhibition of Phosphodiesterase 4 from human U937 cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type U-937
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Phosphodiesterase 4 (CHEMBL2093863)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

8-Methoxyquinolines as PDE4 inhibitors.
Billah M, Buckley GM, Cooper N, Dyke HJ, Egan R, Ganguly A, Gowers L, Haughan AF, Kendall HJ, Lowe C, Minnicozzi M, Montana JG, Oxford J, Peake JC, Picken CL, Piwinski JJ, Naylor R, Sabin V, Shih NY, Warneck JB.
Bioorg Med Chem Lett (2002) 12 : 1617 -1619
PubMed 12039575 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 9 6.79 7.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL42002 1 7.37
CHEMBL40200 1 7.29
CHEMBL289585 1 7.06
CHEMBL39058 1 6.77
CHEMBL43593 1 6.75
CHEMBL295319 1 6.68
CHEMBL607239 1 6.68
CHEMBL40201 1 6.36
CHEMBL444824 1 6.16

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL42002 IC50 = 43.0 nM 7.37
CHEMBL40200 IC50 = 51.0 nM 7.29
CHEMBL289585 IC50 = 88.0 nM 7.06
CHEMBL39058 IC50 = 170.0 nM 6.77
CHEMBL43593 IC50 = 180.0 nM 6.75
CHEMBL295319 IC50 = 210.0 nM 6.68
CHEMBL607239 IC50 = 210.0 nM 6.68
CHEMBL40201 IC50 = 440.0 nM 6.36
CHEMBL444824 IC50 = 700.0 nM 6.16