Compound Detail
CHEMBL444824
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Basic Information
| ChEMBL ID | CHEMBL444824 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MURWOQMZCQAOFK-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
373.2
MW (Da)
4.07
ALogP
5
HBA
1
HBD
87.9
PSA (Ų)
0.75
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 4 CHEMBL2094267 | IC50 | 7.37 | 7.37 | 43.0 | 1 |
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 6.16 | 6.16 | 699.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 4 | IC50 | = | 43.0 | nM | 7.37 | Inhibition of rolipram binding to PDE4 in rat brain | 12039575 |
| Phosphodiesterase 4 | IC50 | = | 700.0 | nM | 6.16 | Inhibition of Phosphodiesterase 4 from human U937 cells | 12039575 |
| Phosphodiesterase 4 | IC50 | = | 699.84 | nM | 6.16 | Inhibition of PDE4 in Homo sapiens (human) U937 cells | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12039575 | 10.1016/s0960-894x(02)00224-x | Phosphodiesterase 4 | 3 |
| 12039575 | 10.1016/s0960-894x(02)00224-x | Phosphodiesterase 3 | 1 |
| - | 10.1007/s00044-012-0457-4 | Phosphodiesterase 4 | 1 |
Data from ChEMBL 36 via Core Engine