Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL765769

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against prostatic 5-alpha reductase in Sprague-Dawley rat
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Steroid 5-alpha-reductase (CHEMBL2096664)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Synthesis of benzanilide derivatives as dual acting agents with alpha 1-adrenoceptor antagonistic action and steroid 5-alpha reductase inhibitory activity.
Yoshida K, Horikoshi Y, Eta M, Chikazawa J, Ogishima M, Fukuda Y, Sato H.
Bioorg Med Chem Lett (1998) 8 : 2967 -2972
PubMed 9873656 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.15 7.41

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL329988 1 7.41
CHEMBL41685 1 7.17
CHEMBL440146 1 7.16
CHEMBL321740 1 7.02
CHEMBL443536 1 6.89
CHEMBL317426 1 6.77
CHEMBL262183 1 6.68
CHEMBL539174 1 6.44
CHEMBL101488 1 6.36
CHEMBL101576 1 6.14
CHEMBL318243 1 6.12
CHEMBL318089 1 6.04
CHEMBL39209 1 6.00
CHEMBL101778 1 5.02
CHEMBL102094 1 4.54
CHEMBL100401 1 4.39
CHEMBL319586 1 4.37

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL329988 IC50 = 39.0 nM 7.41
CHEMBL41685 IC50 = 67.0 nM 7.17
CHEMBL440146 IC50 = 70.0 nM 7.16
CHEMBL321740 IC50 = 96.0 nM 7.02
CHEMBL443536 IC50 = 130.0 nM 6.89
CHEMBL317426 IC50 = 170.0 nM 6.77
CHEMBL262183 IC50 = 210.0 nM 6.68
CHEMBL539174 IC50 = 360.0 nM 6.44
CHEMBL101488 IC50 = 440.0 nM 6.36
CHEMBL101576 IC50 = 730.0 nM 6.14
CHEMBL318243 IC50 = 750.0 nM 6.12
CHEMBL318089 IC50 = 910.0 nM 6.04
CHEMBL39209 IC50 = 1000.0 nM 6.00
CHEMBL101778 IC50 = 9500.0 nM 5.02
CHEMBL102094 IC50 = 29000.0 nM 4.54
CHEMBL100401 IC50 = 41000.0 nM 4.39
CHEMBL319586 IC50 = 43000.0 nM 4.37