Assay Detail
Binding
CHEMBL765788
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Inhibition of Prolyl endopeptidase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Automated parallel synthesis of a tetrahydroisoquinolin-based library: potential prolyl endopeptidase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.68 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL335796 | — | — | 1 | 8.15 |
| CHEMBL139862 | — | — | 1 | 8.05 |
| CHEMBL422281 | — | — | 1 | 7.85 |
| CHEMBL289651 | — | — | 1 | 7.82 |
| CHEMBL342718 | — | — | 1 | 7.77 |
| CHEMBL342651 | — | — | 1 | 7.68 |
| CHEMBL138674 | — | — | 1 | 7.68 |
| CHEMBL139696 | — | — | 1 | 7.64 |
| CHEMBL423002 | — | — | 1 | 7.60 |
| CHEMBL136325 | — | — | 1 | 7.44 |
| CHEMBL334569 | — | — | 1 | 7.27 |
| CHEMBL341749 | — | — | 1 | 7.26 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL335796 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL139862 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL422281 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL289651 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL342718 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL342651 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL138674 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL139696 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL423002 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL136325 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL334569 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL341749 | — | IC50 | = | 55.0 | nM | 7.26 |