Assay Detail
Binding
CHEMBL765807
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In vitro inhibitory activity determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi
9
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Prolylisoxazoles: potent inhibitors of prolyloligopeptidase with antitrypanosomal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 8.84 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL97152 | — | — | 2 | 9.68 |
| CHEMBL95698 | — | — | 1 | 9.59 |
| CHEMBL318284 | — | — | 3 | 9.55 |
| CHEMBL99305 | — | — | 1 | 9.35 |
| CHEMBL100213 | — | — | 1 | 8.12 |
| CHEMBL99237 | — | — | 1 | 7.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL97152 | — | Ki | = | 0.21 | nM | 9.68 |
| CHEMBL95698 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL318284 | — | Ki | = | 0.28 | nM | 9.55 |
| CHEMBL99305 | — | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL318284 | — | Ki | = | 1.25 | nM | 8.90 |
| CHEMBL97152 | — | Ki | = | 1.87 | nM | 8.73 |
| CHEMBL318284 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL100213 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL99237 | — | Ki | = | 72.0 | nM | 7.14 |