Assay Detail
Binding
CHEMBL765820
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Inhibitory activity measured as apparent dissociation constant against Polyamine oxidase (PAO) from pig liver
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase (CHEMBL2105) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
N-2,3-Butadienyl-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.58 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL417844 | — | — | 1 | 7.05 |
| CHEMBL293698 | — | — | 1 | 6.52 |
| CHEMBL59622 | — | — | 1 | 6.16 |
| CHEMBL59623 | — | — | 1 | - |
| CHEMBL292770 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL417844 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL293698 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL59622 | — | Ki | = | 700.0 | nM | 6.16 |
| CHEMBL59623 | — | Ki | = | 310000.0 | nM | - |
| CHEMBL292770 | — | Ki | = | 425000.0 | nM | - |