Assay Detail
Functional
CHEMBL765831
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells
41
Total Activities
41
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 41 | 6.37 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.52 |
| CHEMBL92750 | — | — | 1 | 8.00 |
| CHEMBL327934 | — | — | 1 | 7.34 |
| CHEMBL329339 | — | — | 1 | 7.23 |
| CHEMBL328787 | — | — | 1 | 7.13 |
| CHEMBL316348 | — | — | 1 | 7.10 |
| CHEMBL328506 | — | — | 1 | 7.05 |
| CHEMBL328261 | — | — | 1 | 7.00 |
| CHEMBL330527 | — | — | 1 | 7.00 |
| CHEMBL93451 | — | — | 1 | 6.91 |
| CHEMBL327847 | — | — | 1 | 6.84 |
| CHEMBL313418 | — | — | 1 | 6.84 |
| CHEMBL90766 | — | — | 1 | 6.80 |
| CHEMBL93345 | — | — | 1 | 6.79 |
| CHEMBL330702 | — | — | 1 | 6.79 |
| CHEMBL329198 | — | — | 1 | 6.66 |
| CHEMBL328523 | — | — | 1 | 6.61 |
| CHEMBL91858 | — | — | 1 | 6.55 |
| CHEMBL94286 | — | — | 1 | 6.45 |
| CHEMBL91227 | — | — | 1 | 6.44 |
| CHEMBL330726 | — | — | 1 | 6.38 |
| CHEMBL93894 | — | — | 1 | 6.37 |
| CHEMBL446418 | — | — | 1 | 6.36 |
| CHEMBL91927 | — | — | 1 | 6.30 |
| CHEMBL92730 | — | — | 1 | 6.26 |
| CHEMBL93407 | — | — | 1 | 6.21 |
| CHEMBL94183 | — | — | 1 | 6.18 |
| CHEMBL93463 | — | — | 1 | 6.11 |
| CHEMBL327551 | — | — | 1 | 5.94 |
| CHEMBL330235 | — | — | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL92750 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL327934 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL329339 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL328787 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL316348 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL328506 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL328261 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL330527 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL93451 | — | IC50 | = | 122.0 | nM | 6.91 |
| CHEMBL313418 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL327847 | — | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL90766 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL93345 | — | IC50 | = | 164.0 | nM | 6.79 |
| CHEMBL330702 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL329198 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL328523 | — | IC50 | = | 248.0 | nM | 6.61 |
| CHEMBL91858 | — | IC50 | = | 284.0 | nM | 6.55 |
| CHEMBL94286 | — | IC50 | = | 353.0 | nM | 6.45 |
| CHEMBL91227 | — | IC50 | = | 365.0 | nM | 6.44 |
| CHEMBL330726 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL93894 | — | IC50 | = | 424.0 | nM | 6.37 |
| CHEMBL446418 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL91927 | — | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL92730 | — | IC50 | = | 549.0 | nM | 6.26 |
| CHEMBL93407 | — | IC50 | = | 609.0 | nM | 6.21 |
| CHEMBL94183 | — | IC50 | = | 662.0 | nM | 6.18 |
| CHEMBL93463 | — | IC50 | = | 783.0 | nM | 6.11 |
| CHEMBL327551 | — | IC50 | = | 1144.0 | nM | 5.94 |
| CHEMBL330235 | — | IC50 | = | 1674.0 | nM | 5.78 |
| CHEMBL93690 | — | IC50 | = | 1772.0 | nM | 5.75 |
| CHEMBL328058 | — | IC50 | = | 1847.0 | nM | 5.73 |
| CHEMBL446160 | — | IC50 | = | 2330.0 | nM | 5.63 |
| CHEMBL328804 | — | IC50 | = | 3331.0 | nM | 5.48 |
| CHEMBL91708 | — | IC50 | = | 3443.0 | nM | 5.46 |
| CHEMBL431280 | — | IC50 | = | 5685.0 | nM | 5.25 |
| CHEMBL327918 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL92089 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL93474 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL92777 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL328669 | — | IC50 | = | 10000.0 | nM | 5.00 |