Assay Detail
Binding
CHEMBL765832
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Effective concentration against human Progesterone receptor B isoform expressed in CV-1 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CV-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological activity of novel nonsteroidal progesterone receptor antagonists based on cyclocymopol monomethyl ether.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.62 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48746 | — | — | 1 | 5.89 |
| CHEMBL54270 | — | — | 1 | 5.84 |
| CHEMBL50849 | — | — | 1 | 5.67 |
| CHEMBL51933 | — | — | 1 | 5.52 |
| CHEMBL51788 | — | — | 1 | 5.52 |
| CHEMBL51669 | — | — | 1 | 5.49 |
| CHEMBL48858 | — | — | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48746 | — | EC50 | = | 1295.0 | nM | 5.89 |
| CHEMBL54270 | — | EC50 | = | 1457.0 | nM | 5.84 |
| CHEMBL50849 | — | EC50 | = | 2117.0 | nM | 5.67 |
| CHEMBL51933 | — | EC50 | = | 3005.0 | nM | 5.52 |
| CHEMBL51788 | — | EC50 | = | 3011.0 | nM | 5.52 |
| CHEMBL51669 | — | EC50 | = | 3264.0 | nM | 5.49 |
| CHEMBL48858 | — | EC50 | = | 4020.0 | nM | 5.40 |