Assay Detail
Binding
CHEMBL765836
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Binding affinity was determined against hPR-A (human progesterone receptor) using progesterone radioligand in competitive binding assay
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Alkyl 1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal progesterone receptor modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 8.17 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.47 |
| CHEMBL286446 | — | — | 1 | 9.36 |
| CHEMBL112987 | — | — | 1 | 9.06 |
| CHEMBL325221 | — | — | 1 | 9.02 |
| CHEMBL116007 | — | — | 1 | 8.96 |
| CHEMBL114941 | — | — | 1 | 8.92 |
| CHEMBL116221 | — | — | 1 | 8.82 |
| CHEMBL114607 | — | — | 1 | 8.77 |
| CHEMBL326092 | — | — | 1 | 8.54 |
| CHEMBL332264 | — | — | 1 | 8.49 |
| CHEMBL115174 | — | — | 1 | 8.48 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.46 |
| CHEMBL322108 | — | — | 1 | 8.46 |
| CHEMBL64123 | — | — | 1 | 8.44 |
| CHEMBL8639 | — | — | 1 | 8.32 |
| CHEMBL113098 | — | — | 1 | 8.22 |
| CHEMBL65079 | — | — | 1 | 8.21 |
| CHEMBL325213 | — | — | 1 | 8.18 |
| CHEMBL114553 | — | — | 1 | 7.79 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 7.75 |
| CHEMBL115173 | — | — | 1 | 7.64 |
| CHEMBL114611 | — | — | 1 | 7.61 |
| CHEMBL321243 | — | — | 1 | 7.58 |
| CHEMBL114435 | — | — | 1 | 7.42 |
| CHEMBL294116 | — | — | 1 | 7.30 |
| CHEMBL113099 | — | — | 1 | 7.19 |
| CHEMBL333167 | — | — | 1 | 7.09 |
| CHEMBL67362 | — | — | 1 | 7.08 |
| CHEMBL112058 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL286446 | — | Ki | = | 0.44 | nM | 9.36 |
| CHEMBL112987 | — | Ki | = | 0.87 | nM | 9.06 |
| CHEMBL325221 | — | Ki | = | 0.95 | nM | 9.02 |
| CHEMBL116007 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL114941 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL116221 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL114607 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL326092 | — | Ki | = | 2.9 | nM | 8.54 |
| CHEMBL332264 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL115174 | — | Ki | = | 3.3 | nM | 8.48 |
| CHEMBL103 | PROGESTERONE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL322108 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL64123 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL8639 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL113098 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL65079 | — | Ki | = | 6.1 | nM | 8.21 |
| CHEMBL325213 | — | Ki | = | 6.6 | nM | 8.18 |
| CHEMBL114553 | — | Ki | = | 16.4 | nM | 7.79 |
| CHEMBL1908373 | ONAPRISTONE | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL115173 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL114611 | — | Ki | = | 24.3 | nM | 7.61 |
| CHEMBL321243 | — | Ki | = | 26.5 | nM | 7.58 |
| CHEMBL114435 | — | Ki | = | 38.4 | nM | 7.42 |
| CHEMBL294116 | — | Ki | = | 50.2 | nM | 7.30 |
| CHEMBL113099 | — | Ki | = | 64.0 | nM | 7.19 |
| CHEMBL333167 | — | Ki | = | 80.5 | nM | 7.09 |
| CHEMBL67362 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL112058 | — | Ki | = | 400.0 | nM | 6.40 |