Assay Detail
Binding
CHEMBL765837
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Binding affinity against human progesterone receptor
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Benzylidene 1,2-dihydrochromeno[3,4-f]quinolines, a novel class of nonsteroidal human progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.18 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.47 |
| CHEMBL302362 | — | — | 1 | 9.18 |
| CHEMBL32812 | — | — | 1 | 9.08 |
| CHEMBL344627 | — | — | 1 | 8.89 |
| CHEMBL137103 | — | — | 1 | 8.82 |
| CHEMBL138283 | — | — | 1 | 8.68 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.46 |
| CHEMBL136464 | — | — | 1 | 8.46 |
| CHEMBL101914 | — | — | 1 | 8.44 |
| CHEMBL342426 | — | — | 1 | 8.44 |
| CHEMBL134421 | — | — | 1 | 8.31 |
| CHEMBL335591 | — | — | 1 | 8.26 |
| CHEMBL435822 | — | — | 1 | 8.25 |
| CHEMBL137902 | — | — | 1 | 8.06 |
| CHEMBL342190 | — | — | 1 | 7.90 |
| CHEMBL337262 | — | — | 1 | 7.73 |
| CHEMBL137956 | — | — | 1 | 7.66 |
| CHEMBL135138 | — | — | 1 | 7.61 |
| CHEMBL344644 | — | — | 1 | 7.50 |
| CHEMBL344048 | — | — | 1 | 7.40 |
| CHEMBL139631 | — | — | 1 | 7.27 |
| CHEMBL136915 | — | — | 1 | 7.22 |
| CHEMBL139468 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL302362 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL32812 | — | Ki | = | 0.83 | nM | 9.08 |
| CHEMBL344627 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL137103 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL138283 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL103 | PROGESTERONE | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL136464 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL101914 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL342426 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL134421 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL335591 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL435822 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL137902 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL342190 | — | Ki | = | 12.6 | nM | 7.90 |
| CHEMBL337262 | — | Ki | = | 18.7 | nM | 7.73 |
| CHEMBL137956 | — | Ki | = | 22.1 | nM | 7.66 |
| CHEMBL135138 | — | Ki | = | 24.3 | nM | 7.61 |
| CHEMBL344644 | — | Ki | = | 31.3 | nM | 7.50 |
| CHEMBL344048 | — | Ki | = | 39.7 | nM | 7.40 |
| CHEMBL139631 | — | Ki | = | 53.3 | nM | 7.27 |
| CHEMBL136915 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL139468 | — | Ki | = | 70.0 | nM | 7.16 |