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Assay Detail

CHEMBL765841

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Binding
Binding affinity at human progesterone receptor.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.
Zhi L, Ringgenberg JD, Edwards JP, Tegley CM, West SJ, Pio B, Motamedi M, Jones TK, Marschke KB, Mais DE, Schrader WT.
Bioorg Med Chem Lett (2003) 13 : 2075 -2078
PubMed 12781198 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 7.33 8.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1276308 MIFEPRISTONE 4.0 1 8.96
CHEMBL62227 1 8.35
CHEMBL64294 1 8.17
CHEMBL62761 1 7.91
CHEMBL64123 1 7.89
CHEMBL63870 1 7.82
CHEMBL1908373 ONAPRISTONE 2.0 1 7.75
CHEMBL65079 1 7.71
CHEMBL294116 1 7.35
CHEMBL63788 1 7.35
CHEMBL67362 1 7.08
CHEMBL65522 1 7.07
CHEMBL293409 1 6.84
CHEMBL62798 1 6.69
CHEMBL63610 1 6.61
CHEMBL62714 1 6.56
CHEMBL65380 1 6.43
CHEMBL65054 1 6.41
CHEMBL294265 1 6.32
CHEMBL65307 1 -
CHEMBL62872 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1276308 MIFEPRISTONE Ki = 1.1 nM 8.96
CHEMBL62227 Ki = 4.5 nM 8.35
CHEMBL64294 Ki = 6.8 nM 8.17
CHEMBL62761 Ki = 12.4 nM 7.91
CHEMBL64123 Ki = 12.9 nM 7.89
CHEMBL63870 Ki = 15.0 nM 7.82
CHEMBL1908373 ONAPRISTONE Ki = 18.0 nM 7.75
CHEMBL65079 Ki = 19.3 nM 7.71
CHEMBL294116 Ki = 45.0 nM 7.35
CHEMBL63788 Ki = 45.0 nM 7.35
CHEMBL67362 Ki = 84.0 nM 7.08
CHEMBL65522 Ki = 86.0 nM 7.07
CHEMBL293409 Ki = 144.0 nM 6.84
CHEMBL62798 Ki = 205.0 nM 6.69
CHEMBL63610 Ki = 248.0 nM 6.61
CHEMBL62714 Ki = 273.0 nM 6.56
CHEMBL65380 Ki = 370.0 nM 6.43
CHEMBL65054 Ki = 391.0 nM 6.41
CHEMBL294265 Ki = 476.0 nM 6.32
CHEMBL65307 Ki > 1000.0 nM -
CHEMBL62872 Ki > 1000.0 nM -