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Assay Detail

CHEMBL765845

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
The binding affinity on Human progesterone receptor (hPR-A) using progesterone as radioligand.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Progesterone receptor (CHEMBL208)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.
Zhi L, Tegley CM, Kallel EA, Marschke KB, Mais DE, Gottardis MM, Jones TK.
J Med Chem (1998) 41 : 291 -302
PubMed 9464360 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 8.67 9.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL717 MEDROXYPROGESTERONE ACETATE 4.0 1 9.47
CHEMBL102754 1 9.39
CHEMBL320690 1 9.37
CHEMBL103232 1 9.26
CHEMBL103237 1 9.16
CHEMBL286595 1 9.15
CHEMBL101907 1 9.06
CHEMBL430855 1 8.96
CHEMBL102720 1 8.92
CHEMBL102541 1 8.77
CHEMBL103092 1 8.74
CHEMBL102403 1 8.64
CHEMBL102602 1 8.62
CHEMBL318513 1 8.59
CHEMBL317921 1 8.47
CHEMBL103 PROGESTERONE 4.0 1 8.46
CHEMBL101914 1 8.44
CHEMBL102179 1 8.41
CHEMBL323324 1 8.28
CHEMBL320423 1 8.17
CHEMBL320411 1 8.06
CHEMBL321584 1 7.97
CHEMBL103468 1 7.88
CHEMBL101852 1 7.86

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL717 MEDROXYPROGESTERONE ACETATE Ki = 0.34 nM 9.47
CHEMBL102754 Ki = 0.41 nM 9.39
CHEMBL320690 Ki = 0.43 nM 9.37
CHEMBL103232 Ki = 0.55 nM 9.26
CHEMBL103237 Ki = 0.69 nM 9.16
CHEMBL286595 Ki = 0.7 nM 9.15
CHEMBL101907 Ki = 0.87 nM 9.06
CHEMBL430855 Ki = 1.1 nM 8.96
CHEMBL102720 Ki = 1.2 nM 8.92
CHEMBL102541 Ki = 1.7 nM 8.77
CHEMBL103092 Ki = 1.8 nM 8.74
CHEMBL102403 Ki = 2.3 nM 8.64
CHEMBL102602 Ki = 2.4 nM 8.62
CHEMBL318513 Ki = 2.6 nM 8.59
CHEMBL317921 Ki = 3.4 nM 8.47
CHEMBL103 PROGESTERONE Ki = 3.5 nM 8.46
CHEMBL101914 Ki = 3.6 nM 8.44
CHEMBL102179 Ki = 3.9 nM 8.41
CHEMBL323324 Ki = 5.3 nM 8.28
CHEMBL320423 Ki = 6.8 nM 8.17
CHEMBL320411 Ki = 8.8 nM 8.06
CHEMBL321584 Ki = 10.8 nM 7.97
CHEMBL103468 Ki = 13.3 nM 7.88
CHEMBL101852 Ki = 13.8 nM 7.86