Assay Detail
Binding
CHEMBL765846
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The binding affinity measured using baculovirus-expressed hPR-A in sf21 cells.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2-dihydro-5H-chromeno[3,4-f]quinolines as potent, orally active, nonsteroidal progesterone receptor agonists: the effect of D-ring substituents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 9.07 | 9.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416411 | — | — | 1 | 9.49 |
| CHEMBL106994 | — | — | 1 | 9.49 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 9.47 |
| CHEMBL322485 | — | — | 1 | 9.47 |
| CHEMBL320164 | — | — | 1 | 9.43 |
| CHEMBL104183 | — | — | 1 | 9.32 |
| CHEMBL94749 | — | — | 1 | 9.31 |
| CHEMBL94753 | — | — | 1 | 9.30 |
| CHEMBL319915 | — | — | 1 | 9.26 |
| CHEMBL322575 | — | — | 1 | 9.23 |
| CHEMBL322576 | — | — | 1 | 9.23 |
| CHEMBL286595 | — | — | 1 | 9.15 |
| CHEMBL318409 | — | — | 1 | 9.13 |
| CHEMBL418990 | — | — | 1 | 9.11 |
| CHEMBL322312 | — | — | 1 | 9.03 |
| CHEMBL431807 | — | — | 1 | 8.96 |
| CHEMBL320632 | — | — | 1 | 8.89 |
| CHEMBL104347 | — | — | 1 | 8.89 |
| CHEMBL1162 | NORETHINDRONE | 4.0 | 1 | 8.73 |
| CHEMBL104037 | — | — | 1 | 8.66 |
| CHEMBL107998 | — | — | 1 | 8.62 |
| CHEMBL104451 | — | — | 1 | 8.57 |
| CHEMBL108230 | — | — | 1 | 8.57 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 8.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416411 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL106994 | — | Ki | = | 0.32 | nM | 9.49 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL322485 | — | Ki | = | 0.34 | nM | 9.47 |
| CHEMBL320164 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL104183 | — | Ki | = | 0.48 | nM | 9.32 |
| CHEMBL94749 | — | Ki | = | 0.49 | nM | 9.31 |
| CHEMBL94753 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL319915 | — | Ki | = | 0.55 | nM | 9.26 |
| CHEMBL322575 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL322576 | — | Ki | = | 0.59 | nM | 9.23 |
| CHEMBL286595 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL318409 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL418990 | — | Ki | = | 0.78 | nM | 9.11 |
| CHEMBL322312 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL431807 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL320632 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL104347 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL1162 | NORETHINDRONE | Ki | = | 1.87 | nM | 8.73 |
| CHEMBL104037 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL107998 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL104451 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL108230 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL103 | PROGESTERONE | Ki | = | 3.5 | nM | 8.46 |