Assay Detail
Functional
CHEMBL765903
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Relaxant effect on PGF2-alpha precontracted porcine coronary arteries
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.38 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304927 | — | — | 1 | 6.92 |
| CHEMBL66620 | — | — | 1 | 6.72 |
| CHEMBL67243 | — | — | 1 | 6.52 |
| CHEMBL66323 | — | — | 1 | 5.92 |
| CHEMBL67276 | — | — | 1 | 5.81 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304927 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL66620 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL67243 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL66323 | — | EC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL67276 | — | EC50 | = | 1560.0 | nM | 5.81 |