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Assay Detail

CHEMBL766034

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Evaluated in vitro for its inhibitory activity against Prostaglandin G/H synthase
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Cyclooxygenase (CHEMBL2095157)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Novel 1,2,4-oxadiazoles and 1,2,4-thiadiazoles as dual 5-lipoxygenase and cyclooxygenase inhibitors.
Unangst PC, Shrum GP, Connor DT, Dyer RD, Schrier DJ.
J Med Chem (1992) 35 : 3691 -3698
PubMed 1433181 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.30 7.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1626563 1 7.96
CHEMBL331489 1 7.30
CHEMBL545288 1 7.06
CHEMBL122377 1 7.00
CHEMBL1562610 MECLOFENAMATE SODIUM 4.0 1 7.00
CHEMBL331523 1 6.82
CHEMBL543650 1 6.77
CHEMBL331069 1 6.52
CHEMBL553736 1 6.35
CHEMBL333579 1 6.34
CHEMBL331793 1 6.17
CHEMBL542941 1 6.14
CHEMBL1626562 1 6.10
CHEMBL543891 1 5.80
CHEMBL123459 1 5.72
CHEMBL17091 1 5.66
CHEMBL44957 1 5.52
CHEMBL542464 1 5.36
CHEMBL332103 1 5.33
CHEMBL123210 1 5.14

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1626563 IC50 = 11.0 nM 7.96
CHEMBL331489 IC50 = 50.0 nM 7.30
CHEMBL545288 IC50 = 87.0 nM 7.06
CHEMBL122377 IC50 = 100.0 nM 7.00
CHEMBL1562610 MECLOFENAMATE SODIUM IC50 = 100.0 nM 7.00
CHEMBL331523 IC50 = 150.0 nM 6.82
CHEMBL543650 IC50 = 170.0 nM 6.77
CHEMBL331069 IC50 = 300.0 nM 6.52
CHEMBL553736 IC50 = 450.0 nM 6.35
CHEMBL333579 IC50 = 460.0 nM 6.34
CHEMBL331793 IC50 = 670.0 nM 6.17
CHEMBL542941 IC50 = 730.0 nM 6.14
CHEMBL1626562 IC50 = 800.0 nM 6.10
CHEMBL543891 IC50 = 1600.0 nM 5.80
CHEMBL123459 IC50 = 1900.0 nM 5.72
CHEMBL17091 IC50 = 2200.0 nM 5.66
CHEMBL44957 IC50 = 3000.0 nM 5.52
CHEMBL542464 IC50 = 4400.0 nM 5.36
CHEMBL332103 IC50 = 4700.0 nM 5.33
CHEMBL123210 IC50 = 7200.0 nM 5.14