Assay Detail
Binding
CHEMBL766063
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Platelet-derived growth factor receptor beta autophosphorylation in PAE cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Cell Type | PAE |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Platelet-derived growth factor receptor beta (CHEMBL1913) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Bis(1H-2-indolyl)methanones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.50 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7432 | — | — | 1 | 7.00 |
| CHEMBL7600 | — | — | 1 | 7.00 |
| CHEMBL7735 | — | — | 1 | 6.70 |
| CHEMBL7572 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7432 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL7600 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL7735 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL7572 | — | IC50 | = | 4900.0 | nM | 5.31 |