Assay Detail
Functional
CHEMBL766097
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Concentration required to inhibit antigen-induced release of histamine (AIR) by 50% from rat peritoneal mast cells (RMC) (in vitro)
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | mast cells |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis of 2-(2,3-dihydro-2-oxo-1,3,4-oxadiazol-5-yl) benzo heterocycles. A novel series of orally active antiallergic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.74 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL277454 | — | — | 1 | 6.70 |
| CHEMBL22856 | — | — | 1 | 6.52 |
| CHEMBL22972 | — | — | 1 | 6.46 |
| CHEMBL440463 | — | — | 1 | 6.40 |
| CHEMBL25436 | — | — | 1 | 6.30 |
| CHEMBL22240 | — | — | 1 | 6.05 |
| CHEMBL22034 | — | — | 1 | 6.00 |
| CHEMBL22035 | — | — | 1 | 6.00 |
| CHEMBL22951 | — | — | 1 | 5.92 |
| CHEMBL283153 | — | — | 1 | 5.85 |
| CHEMBL21324 | — | — | 1 | 5.82 |
| CHEMBL74 | CROMOLYN SODIUM | 4.0 | 1 | 5.52 |
| CHEMBL22354 | — | — | 1 | 5.30 |
| CHEMBL21304 | — | — | 1 | 5.22 |
| CHEMBL278389 | — | — | 1 | 4.82 |
| CHEMBL22670 | — | — | 1 | 4.48 |
| CHEMBL279063 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL277454 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL22856 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL22972 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL440463 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL25436 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL22240 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL22034 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL22035 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL22951 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL283153 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL21324 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL74 | CROMOLYN SODIUM | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL22354 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL21304 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL278389 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL22670 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL279063 | — | IC50 | = | 60000.0 | nM | 4.22 |