Assay Detail
Binding
CHEMBL766135
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Affinity for Prostanoid EP1 receptor expressed in COS-7 cells.
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL1811) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of 13,14-dihydro prostaglandin F(1alpha) analogues as potent and selective ligands for the human FP receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.88 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL173499 | — | — | 1 | 6.44 |
| CHEMBL815 | DINOPROST | 4.0 | 1 | 6.42 |
| CHEMBL2220404 | CLOPROSTENOL | 2.0 | 1 | 6.30 |
| CHEMBL425681 | — | — | 1 | 6.15 |
| CHEMBL173299 | — | — | 1 | 6.04 |
| CHEMBL369797 | — | — | 1 | 5.96 |
| CHEMBL36041 | — | — | 1 | 5.87 |
| CHEMBL172250 | — | — | 1 | 5.57 |
| CHEMBL176692 | — | — | 1 | 5.34 |
| CHEMBL434173 | — | — | 1 | 5.30 |
| CHEMBL290969 | — | — | 1 | 5.25 |
| CHEMBL36817 | — | — | 1 | - |
| CHEMBL173811 | — | — | 1 | - |
| CHEMBL173680 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL173499 | — | IC50 | = | 364.0 | nM | 6.44 |
| CHEMBL815 | DINOPROST | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2220404 | CLOPROSTENOL | IC50 | = | 496.0 | nM | 6.30 |
| CHEMBL425681 | — | IC50 | = | 713.0 | nM | 6.15 |
| CHEMBL173299 | — | IC50 | = | 912.0 | nM | 6.04 |
| CHEMBL369797 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL36041 | — | IC50 | = | 1360.0 | nM | 5.87 |
| CHEMBL172250 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL176692 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL434173 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL290969 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL36817 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL173811 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL173680 | — | IC50 | > | 10000.0 | nM | - |