Assay Detail
Binding
CHEMBL766185
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Binding affinity against human progesterone receptor-A (hPR-A)
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonsteroidal progesterone receptor antagonists based on a conformationally-restricted subseries of 6-aryl-1,2-dihydro-2,2,4-trimethylquinolines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 42 | 7.35 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 8.96 |
| CHEMBL433403 | — | — | 1 | 8.82 |
| CHEMBL330527 | — | — | 1 | 8.72 |
| CHEMBL93690 | — | — | 1 | 8.64 |
| CHEMBL327847 | — | — | 1 | 8.51 |
| CHEMBL92750 | — | — | 1 | 8.46 |
| CHEMBL328506 | — | — | 1 | 8.44 |
| CHEMBL313418 | — | — | 1 | 7.95 |
| CHEMBL92089 | — | — | 1 | 7.91 |
| CHEMBL92730 | — | — | 1 | 7.89 |
| CHEMBL329198 | — | — | 1 | 7.85 |
| CHEMBL91927 | — | — | 1 | 7.81 |
| CHEMBL431280 | — | — | 1 | 7.68 |
| CHEMBL446418 | — | — | 1 | 7.62 |
| CHEMBL316348 | — | — | 1 | 7.59 |
| CHEMBL328523 | — | — | 1 | 7.54 |
| CHEMBL90766 | — | — | 1 | 7.54 |
| CHEMBL330702 | — | — | 1 | 7.28 |
| CHEMBL330235 | — | — | 1 | 7.24 |
| CHEMBL327934 | — | — | 1 | 7.20 |
| CHEMBL330726 | — | — | 1 | 7.11 |
| CHEMBL327551 | — | — | 1 | 7.11 |
| CHEMBL93894 | — | — | 1 | 7.06 |
| CHEMBL328804 | — | — | 1 | 7.01 |
| CHEMBL93451 | — | — | 1 | 7.00 |
| CHEMBL329339 | — | — | 1 | 6.95 |
| CHEMBL93463 | — | — | 1 | 6.88 |
| CHEMBL91858 | — | — | 1 | 6.77 |
| CHEMBL93345 | — | — | 1 | 6.75 |
| CHEMBL328058 | — | — | 1 | 6.74 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL433403 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL330527 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL93690 | — | Ki | = | 2.3 | nM | 8.64 |
| CHEMBL327847 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL92750 | — | Ki | = | 3.5 | nM | 8.46 |
| CHEMBL328506 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL313418 | — | Ki | = | 11.2 | nM | 7.95 |
| CHEMBL92089 | — | Ki | = | 12.4 | nM | 7.91 |
| CHEMBL92730 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL329198 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL91927 | — | Ki | = | 15.5 | nM | 7.81 |
| CHEMBL431280 | — | Ki | = | 20.9 | nM | 7.68 |
| CHEMBL446418 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL316348 | — | Ki | = | 25.5 | nM | 7.59 |
| CHEMBL328523 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL90766 | — | Ki | = | 29.1 | nM | 7.54 |
| CHEMBL330702 | — | Ki | = | 53.1 | nM | 7.28 |
| CHEMBL330235 | — | Ki | = | 57.0 | nM | 7.24 |
| CHEMBL327934 | — | Ki | = | 62.5 | nM | 7.20 |
| CHEMBL327551 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL330726 | — | Ki | = | 77.0 | nM | 7.11 |
| CHEMBL93894 | — | Ki | = | 87.0 | nM | 7.06 |
| CHEMBL328804 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL93451 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL329339 | — | Ki | = | 113.0 | nM | 6.95 |
| CHEMBL93463 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL91858 | — | Ki | = | 169.0 | nM | 6.77 |
| CHEMBL93345 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL328058 | — | Ki | = | 184.0 | nM | 6.74 |
| CHEMBL328787 | — | Ki | = | 202.0 | nM | 6.70 |
| CHEMBL446160 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL328261 | — | Ki | = | 449.0 | nM | 6.35 |
| CHEMBL93407 | — | Ki | = | 483.0 | nM | 6.32 |
| CHEMBL91708 | — | Ki | = | 1858.0 | nM | 5.73 |
| CHEMBL92777 | — | Ki | = | 2580.0 | nM | 5.59 |
| CHEMBL94286 | — | Ki | = | 3553.0 | nM | 5.45 |
| CHEMBL93474 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL94183 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL91227 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL327918 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL328669 | — | Ki | > | 10000.0 | nM | - |