Assay Detail
Binding
CHEMBL766409
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Inhibition of Protein kinase B alpha
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RAC-alpha serine/threonine-protein kinase (CHEMBL4282) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-based optimization of novel azepane derivatives as PKB inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.68 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1202518 | — | — | 1 | 8.40 |
| CHEMBL3216643 | — | — | 1 | 8.30 |
| CHEMBL1204095 | — | — | 1 | 6.80 |
| CHEMBL1202525 | — | — | 1 | 6.45 |
| CHEMBL1202519 | — | — | 1 | 5.52 |
| CHEMBL1204097 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1202518 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3216643 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1204095 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL1202525 | — | IC50 | = | 355.0 | nM | 6.45 |
| CHEMBL1202519 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL1204097 | — | IC50 | = | 25000.0 | nM | 4.60 |