Assay Detail
Binding
CHEMBL766675
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for its ability to inhibit calf spleen purine nucleoside phosphorylase (PNP)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Tissue | Spleen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Purine nucleoside phosphorylase (CHEMBL2395) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structure-based design of inhibitors of purine nucleoside phosphorylase. 5. 9-Deazahypoxanthines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.97 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13448 | — | — | 1 | 7.35 |
| CHEMBL8040 | 8-AMINOGUANINE | — | 1 | 7.00 |
| CHEMBL267803 | — | — | 1 | 6.77 |
| CHEMBL8230 | — | — | 1 | 6.70 |
| CHEMBL267312 | — | — | 1 | 6.68 |
| CHEMBL13130 | — | — | 1 | 6.00 |
| CHEMBL219568 | GUANINE | 3.0 | 1 | 5.30 |
| CHEMBL83601 | — | — | 1 | 5.00 |
| CHEMBL1427 | HYPOXANTHINE | — | 1 | 4.77 |
| CHEMBL258513 | — | — | 1 | 4.11 |
| CHEMBL81308 | — | — | 1 | - |
| CHEMBL79346 | — | — | 1 | - |
| CHEMBL84493 | — | — | 1 | - |
| CHEMBL79666 | — | — | 1 | - |
| CHEMBL83421 | — | — | 1 | - |
| CHEMBL82233 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13448 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL8040 | 8-AMINOGUANINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL267803 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL8230 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL267312 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL13130 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL219568 | GUANINE | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL83601 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL1427 | HYPOXANTHINE | Ki | = | 17000.0 | nM | 4.77 |
| CHEMBL258513 | — | Ki | = | 77000.0 | nM | 4.11 |
| CHEMBL81308 | — | Ki | ~ | 5100.0 | nM | - |
| CHEMBL79346 | — | Ki | ~ | 13800.0 | nM | - |
| CHEMBL84493 | — | Ki | = | 150000.0 | nM | - |
| CHEMBL79666 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL83421 | — | Ki | > | 200000.0 | nM | - |
| CHEMBL82233 | — | Ki | ~ | 35000.0 | nM | - |