Assay Detail
Binding
CHEMBL766778
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Displacement of phorbol 12,13-dibutyrate (PDBU) from Protein kinase C alpha
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained analogues of diacylglycerol. 11. Ultrapotent protein kinase C ligands based on a chiral 5-disubstituted tetrahydro-2-furanone template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.48 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116029 | — | — | 1 | 7.92 |
| CHEMBL119303 | — | — | 1 | 7.89 |
| CHEMBL321823 | — | — | 1 | 7.62 |
| CHEMBL94718 | — | — | 1 | 7.55 |
| CHEMBL119907 | — | — | 1 | 7.02 |
| CHEMBL299225 | — | — | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116029 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL119303 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL321823 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL94718 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL119907 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL299225 | — | Ki | = | 138.0 | nM | 6.86 |