Assay Detail
Functional
CHEMBL766783
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Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP1 (% of control ligand, 17-phi-PGE2=80%)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL1811) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 6.29 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40183 | — | — | 1 | 6.52 |
| CHEMBL815 | DINOPROST | 4.0 | 1 | 6.22 |
| CHEMBL2220404 | CLOPROSTENOL | 2.0 | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40183 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL815 | DINOPROST | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2220404 | CLOPROSTENOL | EC50 | = | 760.0 | nM | 6.12 |