Assay Detail
Binding
CHEMBL766784
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Displacement of [3H]PGE-2 from Prostaglandin E receptor EP1 expressed in CHO-KI cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-KI |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Prostaglandin E2 receptor EP1 subtype (CHEMBL1811) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.39 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL290969 | — | — | 1 | 5.96 |
| CHEMBL289373 | — | — | 1 | 5.51 |
| CHEMBL36911 | — | — | 1 | 5.46 |
| CHEMBL289568 | — | — | 1 | 5.00 |
| CHEMBL37244 | — | — | 1 | 5.00 |
| CHEMBL416784 | — | — | 1 | - |
| CHEMBL36901 | — | — | 1 | - |
| CHEMBL286132 | — | — | 1 | - |
| CHEMBL39784 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL290969 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL289373 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL36911 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL289568 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL37244 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL416784 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL36901 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL286132 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL39784 | — | IC50 | > | 10000.0 | nM | - |