Assay Detail

CHEMBL766825

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Binding

Compound was tested in vitro for inhibition of human platelet Prostaglandin G/H synthase 1 at 10 uM

ChEMBL ↗

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Target

Prostaglandin G/H synthase 1 (CHEMBL221) ↗

Open DB target context

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Prostaglandin G/H synthase 1 (CHEMBL221) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Prostaglandin G/H synthase 1

CHEMBL221

Anchored from Assay target.

Protein identity Prostaglandin G/H synthase 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	8 — Homologous single protein target
Curated By	Autocuration

Target

Prostaglandin G/H synthase 1 (CHEMBL221) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Syntheses and biological evaluation of two new naproxen analogs

Kyung Woon Jung, Janda KD, Sanfilippo PJ, Wachter M
Bioorg Med Chem Lett (1996) 6 : 2281 -2282
· DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.46	6.46

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL154	NAPROXEN	4.0	1	6.46

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL154	NAPROXEN	IC50	=	350.0	nM	6.46