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Assay Detail

CHEMBL766948

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Compound was tested for inhibitory activity against prostaglandin synthetase in mouse brain microsomes
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Tissue Brain
Subcellular Microsome
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Prostaglandin-H2 D-isomerase (CHEMBL4334)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Morpholinoalkylindenes as antinociceptive agents: Novel cannabinoid receptor agonists
Kumar V, Alexander MD, Bell MR, Eissenstat MA, Casiano FM, Chippari SM, Haycock DA, Luttinger DA, Kuster JE, Miller MS, Stevenson JI, Ward SJ
Bioorg Med Chem Lett (1995) 5 : 381 -386
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 5.08 5.46

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL13178 PRAVADOLINE 2.0 1 5.46
CHEMBL129525 1 4.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL13178 PRAVADOLINE IC50 = 3500.0 nM 5.46
CHEMBL129525 IC50 = 20000.0 nM 4.70