Assay Detail
Binding
CHEMBL766949
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Concentration required to inhibit 50% activity of prostaglandin synthetase was determined in vitro in mouse brain microsomes
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Microsome |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Antinociceptive (aminoalkyl)indoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.90 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13078 | — | — | 1 | 8.22 |
| CHEMBL274833 | — | — | 1 | 7.82 |
| CHEMBL13288 | — | — | 1 | 7.75 |
| CHEMBL2092862 | — | — | 1 | 6.80 |
| CHEMBL13376 | CLOMETACIN | 4.0 | 1 | 6.70 |
| CHEMBL469 | KETOROLAC | 4.0 | 1 | 6.64 |
| CHEMBL13215 | — | — | 1 | 6.52 |
| CHEMBL273700 | — | — | 1 | 6.30 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.30 |
| CHEMBL274572 | — | — | 1 | 6.16 |
| CHEMBL1907833 | — | — | 1 | 6.16 |
| CHEMBL275241 | — | — | 1 | 6.05 |
| CHEMBL13319 | — | — | 1 | 5.85 |
| CHEMBL12955 | — | — | 1 | 5.85 |
| CHEMBL1907834 | — | — | 1 | 5.52 |
| CHEMBL13178 | PRAVADOLINE | 2.0 | 1 | 5.46 |
| CHEMBL416343 | — | — | 1 | 5.30 |
| CHEMBL273372 | — | — | 1 | 5.30 |
| CHEMBL337134 | — | — | 1 | 5.10 |
| CHEMBL1907835 | — | — | 1 | 5.05 |
| CHEMBL275312 | — | — | 1 | 5.00 |
| CHEMBL13463 | — | — | 1 | 4.92 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 4.89 |
| CHEMBL154 | NAPROXEN | 4.0 | 1 | 4.89 |
| CHEMBL427657 | — | — | 1 | 4.75 |
| CHEMBL2092863 | — | — | 1 | 4.10 |
| CHEMBL273606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13078 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL274833 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL13288 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2092862 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL13376 | CLOMETACIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL469 | KETOROLAC | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL13215 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL273700 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL274572 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL1907833 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL275241 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL13319 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL12955 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1907834 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL13178 | PRAVADOLINE | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL416343 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL273372 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL337134 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL1907835 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL275312 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL13463 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL154 | NAPROXEN | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL427657 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL2092863 | — | IC50 | = | 79000.0 | nM | 4.10 |
| CHEMBL273606 | — | IC50 | > | 30000.0 | nM | - |