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Assay Detail

CHEMBL766997

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro antimalarial activity against Plasmodium falciparum D2
40
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Expert

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Novel endoperoxide antimalarials: synthesis, heme binding, and antimalarial activity.
Taylor DK, Avery TD, Greatrex BW, Tiekink ER, Macreadie IG, Macreadie PI, Humphries AD, Kalkanidis M, Fox EN, Klonis N, Tilley L.
J Med Chem (2004) 47 : 1833 -1839
PubMed 15027875 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 40 5.92 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL269671 ARTEMISININ 3.0 1 8.00
CHEMBL76 CHLOROQUINE 4.0 1 7.52
CHEMBL293578 1 6.50
CHEMBL54899 1 6.30
CHEMBL55396 1 6.30
CHEMBL299577 1 6.30
CHEMBL52248 1 6.22
CHEMBL54903 1 6.00
CHEMBL52634 1 5.92
CHEMBL54629 1 5.89
CHEMBL2374258 1 5.89
CHEMBL301338 1 5.85
CHEMBL52664 1 5.85
CHEMBL53708 1 5.80
CHEMBL53427 1 5.70
CHEMBL52822 1 5.60
CHEMBL52831 1 5.54
CHEMBL52476 1 5.50
CHEMBL390154 1 5.40
CHEMBL53639 1 5.30
CHEMBL2374257 1 5.30
CHEMBL54554 1 5.22
CHEMBL55088 1 5.09
CHEMBL53370 1 5.02
CHEMBL52873 1 -
CHEMBL50573 1 -
CHEMBL300067 1 -
CHEMBL54896 1 -
CHEMBL53784 1 -
CHEMBL300123 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL269671 ARTEMISININ IC50 = 10.0 nM 8.00
CHEMBL76 CHLOROQUINE IC50 = 30.0 nM 7.52
CHEMBL293578 IC50 = 320.0 nM 6.50
CHEMBL54899 IC50 = 500.0 nM 6.30
CHEMBL55396 IC50 = 500.0 nM 6.30
CHEMBL299577 IC50 = 500.0 nM 6.30
CHEMBL52248 IC50 = 600.0 nM 6.22
CHEMBL54903 IC50 = 1000.0 nM 6.00
CHEMBL52634 IC50 = 1200.0 nM 5.92
CHEMBL54629 IC50 = 1300.0 nM 5.89
CHEMBL2374258 IC50 = 1300.0 nM 5.89
CHEMBL52664 IC50 = 1400.0 nM 5.85
CHEMBL301338 IC50 = 1400.0 nM 5.85
CHEMBL53708 IC50 = 1600.0 nM 5.80
CHEMBL53427 IC50 = 2000.0 nM 5.70
CHEMBL52822 IC50 = 2500.0 nM 5.60
CHEMBL52831 IC50 = 2900.0 nM 5.54
CHEMBL52476 IC50 = 3200.0 nM 5.50
CHEMBL390154 IC50 = 4000.0 nM 5.40
CHEMBL53639 IC50 = 5000.0 nM 5.30
CHEMBL2374257 IC50 = 5000.0 nM 5.30
CHEMBL54554 IC50 = 6000.0 nM 5.22
CHEMBL55088 IC50 = 8100.0 nM 5.09
CHEMBL53370 IC50 = 9500.0 nM 5.02
CHEMBL299505 IC50 > 10000.0 nM -
CHEMBL51973 IC50 > 10000.0 nM -
CHEMBL301376 IC50 > 10000.0 nM -
CHEMBL298757 IC50 > 10000.0 nM -
CHEMBL54528 IC50 > 10000.0 nM -
CHEMBL297964 IC50 > 10000.0 nM -
CHEMBL53235 IC50 > 10000.0 nM -
CHEMBL55031 IC50 > 10000.0 nM -
CHEMBL51978 IC50 > 10000.0 nM -
CHEMBL300123 IC50 > 10000.0 nM -
CHEMBL53784 IC50 > 10000.0 nM -
CHEMBL300067 IC50 > 10000.0 nM -
CHEMBL54896 IC50 > 10000.0 nM -
CHEMBL50573 IC50 > 10000.0 nM -
CHEMBL52873 IC50 > 10000.0 nM -
CHEMBL298757 IC50 > 10000.0 nM -