Assay Detail
Binding
CHEMBL767015
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Inhibition of [3H]P4 to progesterone receptor (PR) of human T47D breast carcinoma cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 6-aryl-1,4-dihydrobenzo[d]oxazine-2-thiones as potent, selective, and orally active nonsteroidal progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.49 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282650 | — | — | 1 | 8.52 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | 7.97 |
| CHEMBL417110 | — | — | 1 | 7.00 |
| CHEMBL28164 | — | — | 1 | 7.00 |
| CHEMBL25454 | — | — | 1 | 6.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282650 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL417110 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL28164 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL25454 | — | IC50 | = | 114.0 | nM | 6.94 |