Assay Detail
Functional
CHEMBL767016
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Compound was evaluated for inhibitory activity against HIV-2 protease
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 2 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The development of cyclic sulfolanes as novel and high-affinity P2 ligands for HIV-1 protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.61 | 7.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL18067 | — | — | 1 | 7.76 |
| CHEMBL405657 | — | — | 1 | 6.47 |
| CHEMBL273317 | — | — | 1 | 6.19 |
| CHEMBL18389 | — | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL18067 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL405657 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL273317 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL18389 | — | IC50 | = | 961.0 | nM | 6.02 |