Assay Detail
Binding
CHEMBL767023
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Inhibition of Protein kinase C alpha
8
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.55 | 5.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL368278 | — | — | 1 | 5.22 |
| CHEMBL367625 | — | — | 2 | 4.87 |
| CHEMBL173647 | — | — | 1 | 4.50 |
| CHEMBL173459 | — | — | 1 | 4.42 |
| CHEMBL366734 | — | — | 1 | 4.42 |
| CHEMBL534909 | — | — | 1 | 4.30 |
| CHEMBL557975 | — | — | 1 | 4.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL368278 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL367625 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL367625 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL173647 | — | IC50 | = | 31500.0 | nM | 4.50 |
| CHEMBL173459 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL366734 | — | IC50 | = | 38500.0 | nM | 4.42 |
| CHEMBL534909 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL557975 | — | IC50 | = | 78000.0 | nM | 4.11 |