Assay Detail
Binding
CHEMBL767025
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Inhibition of protein kinase C alpha.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.73 | 6.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL293991 | — | — | 1 | 6.75 |
| CHEMBL55379 | — | — | 1 | 6.54 |
| CHEMBL55662 | — | — | 1 | 6.52 |
| CHEMBL299707 | — | — | 1 | 6.50 |
| CHEMBL58580 | — | — | 1 | 6.46 |
| CHEMBL56081 | — | — | 1 | 6.10 |
| CHEMBL57581 | — | — | 1 | 6.07 |
| CHEMBL291963 | — | — | 1 | 6.00 |
| CHEMBL277931 | — | — | 1 | 5.92 |
| CHEMBL55592 | — | — | 1 | 5.89 |
| CHEMBL58436 | — | — | 1 | 5.82 |
| CHEMBL300817 | — | — | 1 | 5.80 |
| CHEMBL418270 | — | — | 1 | 5.77 |
| CHEMBL56669 | — | — | 1 | 5.70 |
| CHEMBL60816 | — | — | 1 | 5.60 |
| CHEMBL55683 | — | — | 1 | 5.58 |
| CHEMBL57690 | — | — | 1 | 4.98 |
| CHEMBL57556 | — | — | 1 | 4.35 |
| CHEMBL20926 | — | — | 1 | 4.14 |
| CHEMBL418010 | — | — | 1 | 4.10 |
| CHEMBL21162 | — | — | 1 | - |
| CHEMBL423288 | — | — | 1 | - |
| CHEMBL941 | IMATINIB | 4.0 | 1 | - |
| CHEMBL278103 | — | — | 1 | - |
| CHEMBL20867 | — | — | 1 | - |
| CHEMBL20252 | — | — | 1 | - |
| CHEMBL57553 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL293991 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL55379 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL55662 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL299707 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL58580 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL56081 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL57581 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL291963 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL277931 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL55592 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL58436 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL300817 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL418270 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL56669 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL60816 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL55683 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL57690 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL57556 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL20926 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL418010 | — | IC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL21162 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423288 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL941 | IMATINIB | IC50 | > | 100000.0 | nM | - |
| CHEMBL278103 | — | IC50 | = | 240000.0 | nM | - |
| CHEMBL20867 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL20252 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL57553 | — | IC50 | = | 210000.0 | nM | - |