Assay Detail
Binding
CHEMBL767029
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Inhibition of Protein kinase C alpha
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Protein kinase C- inhibitors; structure-activity relationships in bis-indole series
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.82 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.40 |
| CHEMBL7463 | GF-109203 | — | 1 | 8.00 |
| CHEMBL149237 | — | — | 1 | 6.77 |
| CHEMBL269437 | — | — | 1 | 6.55 |
| CHEMBL268744 | — | — | 1 | 6.34 |
| CHEMBL9680 | — | — | 1 | 6.30 |
| CHEMBL429569 | — | — | 1 | 6.20 |
| CHEMBL9333 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL7463 | GF-109203 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL149237 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL269437 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL268744 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL9680 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL429569 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL9333 | — | IC50 | = | 1000.0 | nM | 6.00 |