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Assay Detail

CHEMBL767030

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Protein kinase C alpha
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Protein kinase C alpha type (CHEMBL299)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

4-(Phenylamino)pyrrolopyrimidines: potent and selective, ATP site directed inhibitors of the EGF-receptor protein tyrosine kinase.
Traxler PM, Furet P, Mett H, Buchdunger E, Meyer T, Lydon N.
J Med Chem (1996) 39 : 2285 -2292
PubMed 8691423 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 4.12 4.12

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL75049 1 4.12
CHEMBL306315 1 -
CHEMBL433305 1 -
CHEMBL307062 1 -
CHEMBL72393 1 -
CHEMBL75177 1 -
CHEMBL306081 1 -
CHEMBL74722 1 -
CHEMBL307026 1 -
CHEMBL308582 1 -
CHEMBL311129 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL75049 IC50 = 75000.0 nM 4.12
CHEMBL306315 IC50 > 100000.0 nM -
CHEMBL433305 IC50 > 100000.0 nM -
CHEMBL307062 IC50 > 100000.0 nM -
CHEMBL72393 IC50 > 100000.0 nM -
CHEMBL75177 IC50 > 100000.0 nM -
CHEMBL306081 IC50 > 100000.0 nM -
CHEMBL74722 IC50 > 100000.0 nM -
CHEMBL307026 IC50 > 100000.0 nM -
CHEMBL308582 IC50 > 100000.0 nM -
CHEMBL311129 IC50 > 100000.0 nM -