Assay Detail
Binding
CHEMBL767084
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Inhibition of guinea pig PDE IV
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.48 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 9.00 |
| CHEMBL296477 | — | — | 1 | 8.85 |
| CHEMBL45395 | — | — | 1 | 8.64 |
| CHEMBL297555 | — | — | 1 | 8.07 |
| CHEMBL295976 | — | — | 1 | 7.80 |
| CHEMBL45834 | — | — | 1 | 7.64 |
| CHEMBL47113 | — | — | 1 | 7.18 |
| CHEMBL295669 | — | — | 1 | 6.97 |
| CHEMBL289190 | — | — | 1 | 6.73 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 5.83 |
| CHEMBL46321 | — | — | 1 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42126 | PICLAMILAST | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL296477 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL45395 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL297555 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL295976 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL45834 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL47113 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL295669 | — | IC50 | = | 106.0 | nM | 6.97 |
| CHEMBL289190 | — | IC50 | = | 186.0 | nM | 6.73 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL46321 | — | IC50 | = | 2566.0 | nM | 5.59 |