Compound Detail
CHEMBL295976
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Basic Information
| ChEMBL ID | CHEMBL295976 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FYZBEANPACBLTJ-UHFFFAOYSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
346.8
MW (Da)
4.32
ALogP
4
HBA
1
HBD
60.5
PSA (Ų)
0.88
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 8.7 | 8.25 | 2.0 | 2 |
| Phosphodiesterase 4A CHEMBL3333 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
| Cavia porcellus CHEMBL369 | IC50 | 7.52 | 7.52 | 30.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 4 | IC50 | = | 2.0 | nM | 8.7 | Inhibition of solubilized eosinophil PDE IV | 8201604 |
| Phosphodiesterase 4A | IC50 | = | 16.0 | nM | 7.8 | Inhibitory potency against pig aortic PDE IV | 8201604 |
| Phosphodiesterase 4 | IC50 | = | 16.0 | nM | 7.8 | Inhibition of guinea pig PDE IV | 8201604 |
| Cavia porcellus | IC50 | = | 30.0 | nM | 7.52 | Inhibition of superoxide O2-generation from guinea pig peritoneal eosinophils | 8201604 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8201604 | 10.1021/jm00037a021 | Cavia porcellus | 3 |
| 8201604 | 10.1021/jm00037a021 | Phosphodiesterase 4 | 2 |
| 8201604 | 10.1021/jm00037a021 | Phosphodiesterase 4A | 1 |
Data from ChEMBL 36 via Core Engine