Assay Detail
Functional
CHEMBL686656
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Inhibition of superoxide O2-generation from guinea pig peritoneal eosinophils
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.81 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296477 | — | — | 1 | 7.66 |
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 7.62 |
| CHEMBL295976 | — | — | 1 | 7.52 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.80 |
| CHEMBL295669 | — | — | 1 | 6.77 |
| CHEMBL45395 | — | — | 1 | 6.52 |
| CHEMBL289190 | — | — | 1 | 6.35 |
| CHEMBL297555 | — | — | 1 | 6.32 |
| CHEMBL45834 | — | — | 1 | 6.28 |
| CHEMBL47113 | — | — | 1 | 6.24 |
| CHEMBL46321 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296477 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL42126 | PICLAMILAST | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL295976 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL295669 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL45395 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL289190 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL297555 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL45834 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL47113 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL46321 | — | IC50 | > | 10000.0 | nM | - |