Assay Detail
Binding
CHEMBL767085
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of solubilized eosinophil PDE IV
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Selective type IV phosphodiesterase inhibitors as antiasthmatic agents. The syntheses and biological activities of 3-(cyclopentyloxy)-4-methoxybenzamides and analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.13 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296477 | — | — | 1 | 9.30 |
| CHEMBL42126 | PICLAMILAST | 2.0 | 1 | 9.10 |
| CHEMBL45395 | — | — | 1 | 8.70 |
| CHEMBL295976 | — | — | 1 | 8.70 |
| CHEMBL297555 | — | — | 1 | 8.60 |
| CHEMBL45834 | — | — | 1 | 8.30 |
| CHEMBL47113 | — | — | 1 | 7.75 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 7.70 |
| CHEMBL289190 | — | — | 1 | 7.29 |
| CHEMBL295669 | — | — | 1 | 7.19 |
| CHEMBL46321 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296477 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL42126 | PICLAMILAST | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL45395 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL295976 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL297555 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL45834 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL47113 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL289190 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL295669 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL46321 | — | IC50 | = | 145.0 | nM | 6.84 |