Phosphodiesterase 4A · SINGLE PROTEIN · Sus scrofa
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As of 2026-09-13Protein identity stays anchored to UniProt O77823. Use UniProt O77823 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O77823 as the stable identity anchor, then attach disease evidence before program review.
3',5'-cyclic-AMP phosphodiesterase
Review this target as Phosphodiesterase 4A, mapped to UniProt O77823. ChEMBL maps the protein component as 3',5'-cyclic-AMP phosphodiesterase. Sequence length is 118 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphodiesterase 4A as ChEMBL target CHEMBL3333, mapped to UniProt O77823. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Phosphodiesterase 4A is the right protein anchor across sources, using UniProt O77823 as the stable mapping.
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| Preferred Name | Phosphodiesterase 4A |
| Target Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
| UniProt | O77823 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3',5'-cyclic-AMP phosphodiesterase |
| UniProt Accession | O77823 |
| Component Type | Protein |
| Sequence Length | 118 aa |
3',5'-cyclic-AMP phosphodiesterase
Review this target as Phosphodiesterase 4A, mapped to UniProt O77823. ChEMBL maps the protein component as 3',5'-cyclic-AMP phosphodiesterase. Sequence length is 118 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL42126 | 9.0 | IC50 | 1.0 | Clinical |
| CHEMBL296477 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL45395 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL46142 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL297555 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL300290 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL295976 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL298262 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL45834 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL44790 | 7.46 | IC50 | 35.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 64 | 6.5 |
| assay format | 5 | 4 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-free format | 1 | 1 | 6.3 |