Assay Detail
Binding
CHEMBL767321
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Inhibitory activity against protein phosphatase-1 from rabbit skeletal muscle
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Tissue | Muscle tissue |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 4.88 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 6.37 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 6.24 |
| CHEMBL175630 | — | — | 1 | 4.89 |
| CHEMBL177853 | — | — | 1 | 4.80 |
| CHEMBL368311 | — | — | 1 | 4.75 |
| CHEMBL6951 | — | — | 1 | 4.60 |
| CHEMBL425851 | — | — | 1 | 4.54 |
| CHEMBL175996 | — | — | 1 | 4.31 |
| CHEMBL175576 | — | — | 1 | 4.22 |
| CHEMBL367750 | — | — | 1 | 4.12 |
| CHEMBL368606 | — | — | 1 | - |
| CHEMBL369464 | — | — | 1 | - |
| CHEMBL368167 | — | — | 1 | - |
| CHEMBL176328 | — | — | 1 | - |
| CHEMBL369584 | — | — | 1 | - |
| CHEMBL174701 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL175630 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL177853 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL368311 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL6951 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL425851 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL175996 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL175576 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL367750 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL368606 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL369464 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL368167 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL176328 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL369584 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL174701 | — | IC50 | > | 100000.0 | nM | - |