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Assay Detail

CHEMBL767325

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Binding
Inhibitory concentration against protein phosphatase 1 (PP1) was determined
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Protein phosphatase 1B (CHEMBL2845)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.
McCluskey A, Walkom C, Bowyer MC, Ackland SP, Gardiner E, Sakoff JA.
Bioorg Med Chem Lett (2001) 11 : 2941 -2946
PubMed 11677131 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.09 5.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL100883 1 5.55
CHEMBL100935 1 5.49
CHEMBL8327 DEMETHYL-CANTHARIDIN 1 5.28
CHEMBL99719 1 4.02
CHEMBL319130 1 -
CHEMBL318088 1 -
CHEMBL408609 1 -
CHEMBL102037 1 -
CHEMBL328624 1 -
CHEMBL319542 1 -
CHEMBL316621 1 -
CHEMBL98050 1 -
CHEMBL432193 1 -
CHEMBL316871 1 -
CHEMBL323093 1 -
CHEMBL101983 1 -
CHEMBL98113 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL100883 IC50 = 2820.0 nM 5.55
CHEMBL100935 IC50 = 3220.0 nM 5.49
CHEMBL8327 DEMETHYL-CANTHARIDIN IC50 = 5310.0 nM 5.28
CHEMBL99719 IC50 = 95000.0 nM 4.02
CHEMBL319130 IC50 > 1000000.0 nM -
CHEMBL318088 IC50 > 1000000.0 nM -
CHEMBL408609 IC50 > 1000000.0 nM -
CHEMBL102037 IC50 > 1000000.0 nM -
CHEMBL328624 IC50 > 1000000.0 nM -
CHEMBL319542 IC50 = 312000.0 nM -
CHEMBL316621 IC50 = 570000.0 nM -
CHEMBL98050 IC50 > 1000000.0 nM -
CHEMBL432193 IC50 > 1000000.0 nM -
CHEMBL316871 IC50 = 770000.0 nM -
CHEMBL323093 IC50 = 101000.0 nM -
CHEMBL101983 IC50 > 1000000.0 nM -
CHEMBL98113 IC50 > 1000000.0 nM -