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Assay Detail

CHEMBL767402

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Protein kinase C eta
12
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Protein kinase C eta type (CHEMBL3616)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and biological evaluation of conformationally constrained bicyclic and tricyclic balanol analogues as inhibitors of protein kinase C
Mendoza J, Erik Jagdmann G, Gosnell PA
Bioorg Med Chem Lett (1995) 5 : 2211 -2216
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.89 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL71331 1 9.00
CHEMBL422056 1 8.40
CHEMBL305667 2 7.70
CHEMBL311399 1 7.66
CHEMBL306884 2 7.58
CHEMBL72480 2 7.30
CHEMBL306170 1 6.51
CHEMBL306883 2 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL71331 IC50 = 1.0 nM 9.00
CHEMBL422056 IC50 = 4.0 nM 8.40
CHEMBL305667 IC50 = 20.0 nM 7.70
CHEMBL311399 IC50 = 22.0 nM 7.66
CHEMBL306884 IC50 = 26.0 nM 7.58
CHEMBL72480 IC50 = 50.0 nM 7.30
CHEMBL306170 IC50 = 310.0 nM 6.51
CHEMBL306884 IC50 = 490.0 nM 6.31
CHEMBL72480 IC50 = 1900.0 nM 5.72
CHEMBL306883 IC50 = 2500.0 nM 5.60
CHEMBL306883 IC50 = 2800.0 nM 5.55
CHEMBL305667 IC50 = 4500.0 nM 5.35