Assay Detail
Binding
CHEMBL767471
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Inhibitory concentration required against Protein kinase C (isolated from rat brain) in PKC assay performed with 4 ug phosphatidyl serine:diacylglycerol (2:1)
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Aryl-fused sphingolipids as novel PKC inhibitors with topical antiinflammatory activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 5.03 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84654 | — | — | 1 | 5.57 |
| CHEMBL82271 | — | — | 1 | 5.54 |
| CHEMBL82095 | — | — | 1 | 5.46 |
| CHEMBL83961 | — | — | 1 | 5.43 |
| CHEMBL79293 | — | — | 1 | 5.35 |
| CHEMBL309649 | — | — | 1 | 5.33 |
| CHEMBL86221 | — | — | 1 | 5.30 |
| CHEMBL67166 | SPHINGOSINE | — | 1 | 5.17 |
| CHEMBL86219 | — | — | 1 | 5.04 |
| CHEMBL450573 | — | — | 1 | 5.01 |
| CHEMBL83595 | — | — | 1 | 5.00 |
| CHEMBL315198 | — | — | 1 | 5.00 |
| CHEMBL83281 | — | — | 1 | 5.00 |
| CHEMBL312617 | — | — | 1 | 4.97 |
| CHEMBL80054 | — | — | 1 | 4.96 |
| CHEMBL83733 | — | — | 1 | 4.88 |
| CHEMBL79775 | — | — | 1 | 4.85 |
| CHEMBL315574 | — | — | 1 | 4.80 |
| CHEMBL79330 | — | — | 1 | 4.70 |
| CHEMBL79284 | — | — | 1 | 4.52 |
| CHEMBL311408 | — | — | 1 | 4.44 |
| CHEMBL310407 | — | — | 1 | 4.36 |
| CHEMBL81533 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84654 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL82271 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL82095 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL83961 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL79293 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL309649 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL86221 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL67166 | SPHINGOSINE | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL86219 | — | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL450573 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL83595 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL315198 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL83281 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL312617 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL80054 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL83733 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL79775 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL315574 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL79330 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL79284 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL311408 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL310407 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL81533 | — | IC50 | > | 100000.0 | nM | - |