Compound Detail
CHEMBL84654
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Basic Information
| ChEMBL ID | CHEMBL84654 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AZCHDJYMUOCTQH-LEWJYISDSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
331.5
MW (Da)
3.92
ALogP
3
HBA
3
HBD
66.5
PSA (Ų)
0.43
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C (PKC) CHEMBL2094266 | IC50 | 5.57 | 5.11 | 2700.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C (PKC) | IC50 | = | 2700.0 | nM | 5.57 | Inhibitory concentration required against Protein kinase C (isolated from rat br... | - |
| Protein kinase C (PKC) | IC50 | = | 22200.0 | nM | 4.65 | Inhibition of Protein kinase C of rat brain using phosphatidyl serine: di-acyl g... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(95)00427-U | Protein kinase C (PKC) | 2 |
| - | 10.1016/0960-894X(95)00427-U | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine