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Assay Detail

CHEMBL767473

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Protein kinase C of rat brain using phosphatidyl serine: di-acyl glycerol (2:1)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Protein kinase C (PKC) (CHEMBL2094266)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Aryl-fused sphingolipids as novel PKC inhibitors with topical antiinflammatory activity
Tegeler JJ, Rauckman BS, Hamer RL, Freed BS, Merriman GH, Hellyer L, Ortega-Nanos M, Bailey SC, Kurtz ES
Bioorg Med Chem Lett (1995) 5 : 2477 -2482
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.67 4.88

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL85502 1 4.88
CHEMBL312211 1 4.82
CHEMBL83961 1 4.76
CHEMBL84653 1 4.68
CHEMBL84399 1 4.65
CHEMBL84654 1 4.65
CHEMBL83102 1 4.65
CHEMBL67166 SPHINGOSINE 1 4.63
CHEMBL312617 1 4.62
CHEMBL84652 1 4.62
CHEMBL82271 1 4.58
CHEMBL82126 1 4.46

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL85502 IC50 = 13300.0 nM 4.88
CHEMBL312211 IC50 = 15200.0 nM 4.82
CHEMBL83961 IC50 = 17300.0 nM 4.76
CHEMBL84653 IC50 = 20700.0 nM 4.68
CHEMBL84399 IC50 = 22400.0 nM 4.65
CHEMBL84654 IC50 = 22200.0 nM 4.65
CHEMBL83102 IC50 = 22400.0 nM 4.65
CHEMBL67166 SPHINGOSINE IC50 = 23400.0 nM 4.63
CHEMBL312617 IC50 = 23700.0 nM 4.62
CHEMBL84652 IC50 = 24100.0 nM 4.62
CHEMBL82271 IC50 = 26200.0 nM 4.58
CHEMBL82126 IC50 = 34500.0 nM 4.46